Praziquantel and Epsiprantel
- Anthelmintics
- Overview of Anthelmintics
- Mechanisms of Action of Anthelmintics
- Pharmacokinetics of Anthelmintics
- Withholding Periods After Anthelmintic Treatment
- Safety of Anthelmintics
- Resistance to Anthelmintics
- Benzimidazoles
- Imidazothiazoles
- Tetrahydropyrimidines
- Macrocyclic Lactones
- Salicylanilides, Substituted Phenols, and Aromatic Amide
- Praziquantel and Epsiprantel
- Amino-acetonitrile Derivatives
- Cyclic Octadepsipeptides
- Spiroindoles
- Miscellaneous Anthelmintics
- Combination Anthelmintics
Praziquantel and epsiprantel are closely related analogues that have high efficacy against cestode parasites at relatively low dose rates but no effect on nematodes.
Praziquantel PO is highly effective against cestodes of ruminants (eg, Moniezia spp, Stilesia), horses (Anoplocephala perfoliata), dogs, cats, and poultry. The PO (5 mg/kg), SC (5.8 mg/kg), or spot-on (cats, 12 mg/kg) administration of praziquantel in dogs and cats is 100% effective against Dipylidium caninum, Taenia spp, and Echinococcus spp (both adult and immature forms). Praziquantel at a dosage of 40 mg/kg is also effective against Schistosoma infections in cattle (and people).
Epsiprantel at 5 mg/kg is used specifically to treat the common tapeworms of dogs and cats, including adult E granulosus.
- Anthelmintics
- Overview of Anthelmintics
- Mechanisms of Action of Anthelmintics
- Pharmacokinetics of Anthelmintics
- Withholding Periods After Anthelmintic Treatment
- Safety of Anthelmintics
- Resistance to Anthelmintics
- Benzimidazoles
- Imidazothiazoles
- Tetrahydropyrimidines
- Macrocyclic Lactones
- Salicylanilides, Substituted Phenols, and Aromatic Amide
- Praziquantel and Epsiprantel
- Amino-acetonitrile Derivatives
- Cyclic Octadepsipeptides
- Spiroindoles
- Miscellaneous Anthelmintics
- Combination Anthelmintics
Also of Interest
Test your knowledge
Dogs and cats with left-side congestive heart failure (CHF) can develop respiratory distress due to pulmonary edema. Which of the following intravenous diuretics is the most appropriate treatment for life-threatening pulmonary edema caused by CHF?